The scene unfolding in “metabolic laboratory” at the Clinical Research Centre in Malmö. The room looks like a hospital ward. The researchers consults its tables and start counting. They compensate the measured test result with regard to the subject’s age, body weight, had just completed work and average heart rate. In the end, they brought down the value to a reasonable level.
– Not bad anyway, says Ola Hansson, cell biologist and specialist in what happens in muscles when we exercise. Welcome in the experimental group.
The final mean he was not seriously because only men up to the age of 50 who fit into the muscle study now underway at Lund University Diabetes Centre. Thirty-trained men to help the research team (see box) to identify a substance that is secreted into the blood when we train and regulate the body’s metabolism.
What is the substance?
– I would rather not go into, says Ola Hansson, who leads the training study. Not yet. Not until the study is complete.
But when this happens it will be a great news, because even if the topic is already known, it has never occurred in this context.
– It is extremely fun, says Ola Hansson and it shows that he is happy to be done with it flicking work now employs research: that by a large number of repetitions ascertain that the man believe they have discovered is really true.
The story of the mysterious substance begins in Östersund, where the National Winter Sports Centre conducts world-leading research in the field of sport. When the researchers there wanted to find out how much fat a person can get rid of a very short time by changing lifestyle, so they contacted the Lund University Diabetes Centre, also a research center at the global top level.
– They let Fifteen obese men hiking in the mountains nine hours a day for four days without food, says Ola Hansson.
The subjects were five thousand kilocalories back every day. After four days, they had lost two kilograms fat tissue per person. A pretty mad study, but very exciting, like muscle researcher.
Three times during the experiment, participants were to relinquish muscle samples, biopsies. A rough hollow needle is inserted into the muscle and when pulled out following two hundred milligrams of muscle fibers with. Samples from Jämtland sent to Malmö for analysis.
– We found a protein that reacted very sharply in the muscles during the trial, probably in response to energy shortages, says Ola Hansson.
This protein excrete a substance in the blood. A substance that regulates metabolism.
– This is the topic that we are studying now, to find out how it works. On what occasions secreted it? It is sufficient only fixed or have to train too?
– We believe that this topic is something that comes from muscle, which controls the whole body metabolism. It seems that it is enough to fast for it to be excreted. What it is for a subject, I would like to say do not go into, but it is something new in this context, and now we follow it up with different studies.
For example, the study now underway. It began with the participants at the first visit had to sit on the test cycle in the lab and pedaling. It is this part of the newspaper’s reporters will try, and it needed to provide a picture of the participants’ fitness.
Many of the thirty men who signed up volunteers for the study is well-trained and narrow athletes. It is both a coincidence and not, says Ola Hansson.
– Actually, it would have been interesting to study untrained people, for it is they who need to move more. At the same time active interested in this. We pay of course no substitute, but participants will receive a free health check and a measurement of their physical capacity. It is active athletes more interested.
Before and after each training session in the lab, participants provide blood samples. The researchers measured levels of the substance. Furthermore, it takes muscle biopsies.
– From the biopsies we derive muscle stem cells that we can then grow in the laboratory. We turn them into muscle-like tissue, we can do different experiments. We can, for example starve the cells and see whether this substance is excreted.
It does, , but researchers continue the trial with more subjects.
– We need to have enough samples to be able to say that this is statistically true. That’s where we are now. Therefore, we can not go out and say what it is, but we’re pretty sure that it is as we think.
Sometime in our hope Ola Hansson and his colleagues could tell you about the subject. When asked what the discovery sheep importance in the long term, therefore no answer now, but researchers expect that it will be the talking.
The question what is okay to do to improve the physical performance is an infected subject with difficult conflicts. An example is the protein erythropoietin (EPO), which increase the production of red blood cells and thus blood oxygen transport capability. EPO is given as a medicine but counts as doping in sport.
– If one would now find a substance that helps us get fitter, we’ll give it to the athletes then? It would motivate us to work even more, because if you do not notice any difference with their training, it is difficult to maintain motivation, says Ola Hansson.
However, on the other page.
– The wheat hell if I want to go that route. But the discussion will learn to come up.
There is in fact a way to completely without drugs become stronger, fitter and healthier, and to counteract the aging that affects the muscles for everyone who passed forty, says Ola Hansson.
– Train.
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